Root-originating dentinal defects: methodological aspects and clinical relevance

It was in the 1980s when the association between root-filling procedures and dentinal microcracks was made. Nowadays, root-originating microcracks, also known as dentinal defects, are recognized as a possible precursor that is part of the longitudinal process of root-originating fractures. The presence of dentinal defects has been shown to significantly decrease the outcome through a periapical microsurgery model. Several in vitro articles have been published in the past years in regards to dentinal defects, but most of them have serious methodology concerns that will be discussed in this review. A total grasp of the development and the role dentinal defects play in endodontics is crucial to the specialty. This review aims to discuss dentinal defects and their causative factors and the research models that have been used and their clinical significance. Through a comprehensive critical review of the literature, this article will express the need for further in vivo clinical research and better ex vivo methods that can replicate the clinical setting to answer several remaining questions about the development of and the role dentinal defects play in endodontics.